Judd Apatow was listening to an interview of Amy Schumer on The Howard Stern Show and he couldn’t believe how funny she was when she was talking about her father’s battle with multiple sclerosis. He reached out to her and asked if she wanted to make a movie based on her family life. Trainwreck was born and Apatow wound up directing the movie.
Some of the storyline of Trainwreck is based on Schumer’s real life. Her dad suffers from multiple sclerosis and she was hesitant to talk about it in the movie but she knew some of her viewers could relate to it and in the end she thought it was important to keep it in.
Schumer wanted LeBron James in the movie so badly that she not only wrote the part expressly for him, but in the script she also described what kind of Tom Ford suits he would be wearing in the movie with the hopes of enticing him to take the role. That was really nice of her, as we all know King James is really strapped for cash.
Apatow really wanted Bill Hader to play opposite Schumer, but he needed to see if the two had any chemistry. So instead of doing an audition or screen test, he asked Amy and Bill out to dinner and then used the experience as a secret screen test.
In the movie, Aaron, played by Hader, shares the story of his first kiss. Well, it was the story of Hader’s first kiss in real life. He told Schumer his story and she insisted that they add it into the script.
Daniel Radcliffe makes a very short cameo in the movie as a dog walker who is walking way too many dogs. When a picture leaked of Radcliffe in full dog-walker gear, the internet went wild and there was a rumor going around that he quit the business to become a dog walker.
Apparently, Schumer is such a huge The Royal Tanenbaums fan that she paid homage to it in the scene where she discovers her dad has cancer. She says the line, "Where's the doctor?" which is the exact same line Angelica Huston's character says when she finds out she herself has cancer.